A case of pure red cell aplasia in a chronic hemodialysis patient with erythropoietin-resistant anemia.
- Author:
Jisook HAHN
1
;
Hye Young KIM
;
Ki Won MOON
;
Ki Hyeong LEE
;
Soon Kil KWON
;
Kyeong Seob SHIN
;
Jae Ho EARM
Author Information
1. Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea. hyekim@chungbuk.ac.kr
- Publication Type:Case Report
- Keywords:
Pure Red Cell Aplasia;
Erythropoietin;
Chronic Renal Failure
- MeSH:
Anemia*;
Antibody Formation;
Bone Marrow Examination;
Erythropoietin;
Female;
Hemorrhage;
Humans;
Iron;
Kidney Failure, Chronic;
Middle Aged;
Red-Cell Aplasia, Pure*;
Renal Dialysis*
- From:Korean Journal of Medicine
2004;67(Suppl 3):S794-S798
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The resistance to recombinant human erythropoietin (r-HuEPO) in patients with chronic renal failure can develop in conditions such as iron deficiency, chronic bleeding, or chronic inflammatory disease. Recently, there have been several case reports of pure red cell aplasia due to antibody production to r-HuEPO in chronic hemodialysis patients. A 59-year old female undergoing chronic hemodialysis responded well to r-HuEPO for 6 years. But, a rapidly progressive anemia was then noted which was unresponsive to maximal doses of r-HuEPO and the patient became transfusion-dependent. Bone marrow examination showed absence of red cell precursors. A detailed search for the cause of this pure red cell aplasia was unrevealing. We conclude that although very rare, pure red cell aplasia should be considered in evaluating chronic hemodialysis patients with erythropoietin-resistant anemia.
