Serum adiponectin predicts post-stroke depression in patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2018.08.004
- VernacularTitle:血清脂联素预测缺血性卒中患者的卒中后抑郁
- Author:
Zhao CHEN
1
,
2
;
Le HOU
;
Dan LI
;
Guoqing CAI
;
Yu QIU
;
Haishan SHI
;
Yuping NING
Author Information
1. 510370 广州医科大学附属脑科医院惠爱医院神经内科
2. 523000 东莞市常平医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Depression;
Adiponectin;
Biomarkers;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2018;26(8):577-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum adiponectin (APN) for post-stroke depression (PSD) in patients with ischemic stroke. Methods Patients with acute ischemic stroke admitted to the Departments of Neurology, the Affiliated Brain Hospital of Guangzhou Medical University, and Dongguan Changping Hospital were enrolled prospectively from September 2016 to January 2018. Serum APN levels were measured by radioimmunoassay the next day after admission. PSD was diagnosed by using the Diagnostic and Statistical Manual of Mental Disorders (4th Edition) at one month after discharge. The baseline clinical features in the PSD group and the non-PSD group were compared. Multivariable logistic regression analysis was used to determine the risk factors for PSD. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of APN for PSD. Results A total of 220 patients were enrolled, including 57 (25.9%) in the PSD group and 163 (74.1%) in the non-PSD group. The proportion of patients with diabetes (P=0.020) and living alone (P=0.012), as well as age (P=0.17), homocysteine (P=0.009), C-reactive protein ( P=0.001), and National Institutes of Health Stroke Scale score ( P=0.007) in the PSD group were significantly higher than those in the non-PSD group, while the APN level was significantly lower than that in the non-PSD group (P=0.003). Multivariate logistic regression analysis showed that the 4th quartile of serum APN level was used as a reference, the 1st quartile of APN level was an independent risk factor for PSD (odds ratio, 4 .202, 95% confidence interval 1.401-12.067; P=0.013). ROC curve analysis showed that the area under the curve of serum APN level for predicting PSD was 0.642 (95% confidence interval 0.564-0.721; P=0.001). The optimal cutoff value was 6.4 mg/L, and its sensitivity of predicting PSD was 63.2%, the specificity was 63.8%, the positive predictive value was 83.3%, and the negative predictive value was 57 .7%. Conclusion Serum APN has a certain predictive value for PSD in patients with ischemic stroke.
