Correlation between total MRI cerebral small vessel disease score and cognitive function
10.3760/cma.j.issn.1673-4165.2018.07.009
- VernacularTitle:总MRI脑小血管病评分与认知功能的相关性
- Author:
Yucheng GU
1
,
2
;
Renyuan LIU
;
Ruomeng QIN
;
Xin CHEN
;
Junhui ZOU
;
Yongcheng JIANG
;
Yun XU
Author Information
1. 210008 南京大学医学院附属鼓楼医院神经内科
2. 210009 东南大学医学院
- Keywords:
Cerebral Small Vessel Diseases;
Cognition Disorders;
Cognition;
Magnetic Resonance Imaging;
Neuroimaging
- From:
International Journal of Cerebrovascular Diseases
2018;26(7):521-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between total MRI cerebral small vessel disease (SVD) score and overall cognitive functions and different cognitive domains.Methods Form January 2017 to June 2018,subjects aged 45-80 years and without dementia were recruited from the Neurology clinic,wards,Nanjing Drum Tower Hospital,the Affdiated Hospital of Nanjing University Medical School and communities.The overall cognitive function,executive function,processing speed,working memory,language function,visual-spatial ability,and depression were assessed with the related scale in all subjects.3.0 T MRI (T1-weighted imaging,T2-weighted imaging,diffusion-weighted imaging,liquid-attenuated inversion recovery sequence,and susceptibility-weighted imaging) was used to identify white matter hyperintensities,lacunar foci,microbleeds,and enlargement of perivascular space.The total SVD score was calculated.Results A total of 217 subjects were enrolled,including 24 normal middle-aged and elderly,65 at risk of cerebrovascular disease,128 with SVD changes in imaging findings.Multivariate linear regression analysis showed that after adjusting for possible confounding factors,the total SVD score and overall cognitive function (β =-0.105,95％ confidence interval [CI]-0.201--0.010;P =0.030),executive function (β =-0.135,95 ％ C!-0.216--0.054;P =0.001),and language function (β =-0.095,95％ CI-0.182--0.008;P =0.032) showed a significantly independent negative correlation.Conclusion The total SVD score was negatively correlated with the overall cognitive function,executive function,and impairment of language function.
