Cold wave-induced stroke: the roles of renin-angiotensin system and matrix metalloproteinase-9
10.3760/cma.j.issn.1673-4165.2018.07.007
- VernacularTitle:寒潮诱发卒中:肾素-血管紧张素系统和基质金属蛋白酶-9的作用
- Author:
Chunguang LI
1
;
Ying PENG
;
Sheng TAN
;
Ruxun HUANG
Author Information
1. 南方医科大学珠江医院神经内科
- Keywords:
Stroke;
Cold Temperature;
Seasons;
Renin-Angiotensin System;
Matrix Metalloproteinase 9;
Time Factors;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2018;26(7):510-515
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiological studies and clinical observations have indicated that cold temperature can trigger the occurrence of stroke in individuals at high risk.However,the underlying mechanisms are still unknown.Matrix metalloproteinase-9 (MMP-9) has been found to be associated with the formation,progression and rapture of atherosclerotic plaques and cerebral aneurysms,which is the pathological basis of stroke.Cold temperature activates renin-angiotensin system (RAS) in circulation and tissue.Angiotensin Ⅱ has been implicated in the inducing MMP-9 expression and activation.An increase of MMP-9 may facilitate destabilization and rupture of atherosclerotic plaques or cerebral aneurysms,resulting in the occurrence of stroke.
