DNA methylation and atherosclerosis
10.3760/cma.j.issn.1673-4165.2018.06.015
- VernacularTitle:DNA甲基化与动脉粥样硬化
- Author:
Xiaoting WANG
1
,
2
;
Zhangyong XIA
;
Chengju HUO
;
Ru BAN
;
Xin ZHAO
;
Liuying ZHANG
;
Guifeng ZHANG
;
Li LI
;
Caisheng LU
;
Bo LIU
Author Information
1. 271000 泰安,泰山医学院研究生部
2. 252000 聊城市人民医院神经内科,山东省心脑血管病微创治疗工程技术研究中心
- Keywords:
Atherosclerosis;
DNA Methylation;
Epigenesis,Genetic
- From:
International Journal of Cerebrovascular Diseases
2018;26(6):473-477
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic systemic inflammatory disease caused by the interaction of environment and genetic factors. Epigenetic modification is a bridge between environmental factors and genetic factors. DNA methylation is an important regulatory mode of epigenetic modification, which can regulate gene expression at the pre-transcriptional level. Studies have shown that DNA methylation plays an important role in the occurrence and development process of atherosclerosis. Therefore, atherosclerosis-related DNA demethylation, especially carotid atherosclerosis-related DNA demethylation, can be achieved by natural or synthetic DNA demethylases, thereby achieving the purpose of preventing or treating atherosclerotic cerebrovascular disease. This article reviews DNA methylation and its relationship with atherosclerosis and DNA demethylation therapy.
