Effect of prior statin use on outcome after intravenous thrombolysis in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2018.06.005
- VernacularTitle:发病前使用他汀类药物对急性缺血性卒中患者静脉溶栓治疗后转归的影响
- Author:
Liu HE
1
;
Zhong ZHANG
;
Lei WANG
;
Xi ZHU
;
Sheng FANG
;
Shuai JIANG
;
Ni LI
;
Guanghui XU
;
Jiaojiao GONG
;
Shanshan YANG
;
Yetao LUO
Author Information
1. 西南交通大学附属医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Thrombolytic Therapy;
Tissue Plasminogen Activator;
Treatment Outcome
- From:
International Journal of Cerebrovascular Diseases
2018;26(6):422-427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of prior statin use on outcome after intravenous thrombolysis in patients with acute ischemic stroke. Methods Consecutive patients with acute ischemic stroke treated with intravenous thrombolysis at the Department of Neurology, the Third People's Hospital of Chengdu from July 2014 to August 2017 were enrolled, and divided into the statin use group and nonstatin use group according to prior statin use. Symptomatic intracranial hemorrhage and the outcome at 90 days after onset (good outcome and poor outcome were defined as the modified Rankin Scale score 0-2 and > 2, respectively) in the two groups were compared, and multivariate logistic regression analysis was used to identify the effect of prior statin use on the outcome. Results A total of 327 patients were enrolled, including 68 (20. 80％ ) in the statin use group, and 59 (79. 20％ ) in the nonstatin use group. There were no significant differences in the incidence symptomatic intracranial hemorrhage (7. 35％ vs. 10. 04％; χ2 = 0. 453, P = 0. 501), good outcome rate at 90 days (69. 12％ vs. 66. 02％; χ2 = 0. 232, P = 0. 630), and mortality rate (7. 35％ vs. 7. 34％; P = 1. 000) between the statin use group and the nonstatin use group. Multivariable logistic regression analysis showed that prior statin use were not an independent risk factor for symptomatic intracranial hemorrhage (odds ratio 0. 658, 95％ confidence interval 0. 233-1. 857; P = 0. 429) and poor outcome at 90 dafter onset (odds ratio 0. 848, 95％ confidence interval 0. 424-1. 696; P = 0. 641) in patients treated with intravenous thrombolysis. Conclusion Prior statin use is not associated with symptomatic intracranial hemorrhage and outcome after intravenous thrombolysis in patients with acute ischemic stroke.
