Selective intra-arterial cold saline infusion combined with intravascular reperfusion for acute ischemic stroke with large artery occlusion: a preliminary safety and feasibility study
10.3760/cma.j.issn.1673-4165.2018.06.002
- VernacularTitle:选择性动脉内冷盐水灌注联合血管内再灌注治疗大动脉闭塞性急性缺血性卒中:安全性和可行性初步研究
- Author:
Shuanggen ZHU
1
;
Guisu LI
;
Fu LIN
;
Jinsong CHEN
;
Changyu LI
;
Wusheng ZHU
Author Information
1. 518109,深圳市龙华区人民医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Endovascular Procedures;
Thrombolytic Therapy;
Thrombectomy;
Stents;
Hypothermia,Induced;
Sodium Chloride;
Infusions,Intra-Arterial;
Treatment Outcome
- From:
International Journal of Cerebrovascular Diseases
2018;26(6):407-412
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily investigate the safety and feasibility of intra-arterial cold saline infusion combined with intravascular reperfusion for acute ischemic stroke with large artery occlusion. Methods From March 2016 to March 2018, consecutive acute ischemic stroke patients with large artery occlusion within 8 h after onset admitted to the Department of Neurology, the People's Hospital of Longhua District, Shenzhen and recanalized successfully after endovascular treatment were enrolled. After recanalization, cold saline was infused through the guiding catheter via the ipsilateral guilty vessel (10 ℃, 33 ml/min for 30 min). Results A total of 20 patients were enrolled, including 15 males. Their median age was 67 years (interquartile range, 53-80 years). Fifteen patients were treated with thrombolysis. A median onset-to-needle time was 300 min (interquartile range, 260-360 min). During the infusion of cold saline, the lowest rectal temperature was only decreased 0. 1 ℃, but within 5 min after completion of perfusion, it returned to the temperature before perfusion. Complications associated with intra-arterial hypothermia were not observed. The median National Institutes of Health Stroke Scale score was significantly decreased from 21 (interquartile range 15-55) before needle to 15 (interquartile range 10-16; Z = -4. 549, P < 0. 001) at discharge. Conclusion Selective intra-arterial cold saline infusion combined with intravascular reperfusion for acute ischemic stroke with large artery occlusion is safe and feasible.
