Neuroprotective effects of selective estrogen receptor modulators in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2018.05.008
- VernacularTitle:选择性雌激素受体调节剂在脑缺血中的神经保护作用
- Author:
Di LUAN
1
;
Chuanjin CHEN
;
Yang XU
;
Shoucai ZHAO
Author Information
1. 皖南医学院附属弋矶山医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Selective Estrogen Receptor Modulators;
Receptors,Estrogen;
Tamoxifen;
Raloxifene Hydrochloride;
Bazedoxifene;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2018;26(5):368-372
- CountryChina
- Language:Chinese
-
Abstract:
Selective estrogen receptor modulators tamoxifen,raloxifene,and bazedoxifene reduce neuronal death through the mechanisms of anti-inflammation,antioxidant stress,and inhibition of glutamate excitotoxicity.They play a neuroprotective role in cerebral ischemia and may become a new neuroprotective agent for the treatment of ischemic stroke.
