Comparison of safety and efficacy between direct thrombectomy and bridging therapy in acute large vessel occlusion stroke within 4.5 h of onset
10.3760/cma.j.issn.1673-4165.2018.04.003
- VernacularTitle:急性大血管闭塞卒中发病4.5 h内直接取栓与桥接治疗的安全性和有效性比较
- Author:
Yifeng WANG
1
;
Yun XU
;
Xueling ZHANG
;
Junshan ZHOU
;
Hongchao SHI
;
Jingwei LI
Author Information
1. 210008,南京大学医学院附属鼓楼医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Thrombectomy;
Endovascular Procedures;
Thrombolytic Therapy;
Infusions;
Intravenous,Propensity Score;
Treatment Outcome
- From:
International Journal of Cerebrovascular Diseases
2018;26(4):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the safety and efficacy of directly thrombectomy and bridging therapy in patients with acute large vessel occlusion stroke within 4.5 h of onset.Methods From April 2014 to September 2017, patients with acute large vessel occlusion stroke treated with emergency mechanical thrombectomy in Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School were collected. The patients who were eligible for intravenous thrombolysis and whose onset time was ≤4.5 h were selected. The propensity score matching analysis and McNemar test were used to compare the safety and efficacy of direct mechanical thrombectomy and bridging therapy. Results A total of 41 patients with acute large vessel occlusion stroke were enrolled.The final propensity score matching was 12 pairs.In the direct thrombectomy group, the time from door to femoral artery sheath placement was significantly reduced (P=0.03), but there was no significant difference in the good functional outcome rate, mortality rate, and incidence of symptomatic intracranial hemorrhage between the two groups of patients at 90 d(P>0.05).Conclusion It is safe and effective to start direct mechanical thrombectomy within 4.5 h of onset in patients with acute large vessel occlusion stroke and can significantly shorten the time of vascular recanalization.
