Roles of regulatory T cells in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2018.02.009
- VernacularTitle:调节性T细胞在脑缺血中的作用
- Author:
Yao WANG
1
;
Xuezhu ZHANG
Author Information
1. 天津中医药大学
- Keywords:
Stroke;
Brain Ischemia;
T-Lymphocytes;
Regulatory;
Inflammation;
Immune System
- From:
International Journal of Cerebrovascular Diseases
2018;26(2):150-154
- CountryChina
- Language:Chinese
-
Abstract:
After cerebral ischemia,peripheral lymphocytes infiltrate to brain parenchyma through the damaged blood-brain barrier. They act synergistically w ith microglia, etc., promote the release of proinflammatory cytokines,form a continuously amplified inflammatory cascade,and aggravate nerve injury. Regulatory T cells can negatively regulate the immune function, and maintain homeostasis and immune tolerance by inhibiting the activation of a variety of inflammatory cells and release of proinflammatory cytokines.This article review s the roles and mechanisms of regulatory T cells in cerebral ischemia.
