Roles of Toll-like receptor 4 in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2018.01.012
- VernacularTitle:Toll样受体4在脑缺血中的作用
- Author:
Liangzhu WANG
1
;
Yingzhu CHEN
;
Beilei CHEN
;
Liu YANG
;
Hailong YU
Author Information
1. 116044,大连医科大学
- Keywords:
Brain Ischemia;
Toll-Like Receptor 4;
Inflammation;
Neuroprotective Agents;
Ischemic Preconditioning
- From:
International Journal of Cerebrovascular Diseases
2018;26(1):63-67
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,studies have shown that inflammation is an important factor in secondaryischemic injury.The exploration of the related mechanisms of the occurrence of inflammation has become ahot spot in the field of cerebral ischemia.Toll-like receptor 4 (TLR4) signaling pathway is one of theclassical inflammatory pathways.Studies have shown that TLR4 is involved in the early inflammatoryresponse after cerebral ischemic injury and the late nerve repair.This article reviews the research progress ofthis signaling pathway in cerebral ischemia injury,so as to seek a therapeutic target against inflammatoryinjury caused by cerebral ischemia through the analysis of its potential research direction.
