Correlation of short-term blood pressure variability and outcome after intravenous thrombolysis in patients with acute ischemic stroke: a Meta-analysis
10.3760/cma.j.issn.1673-4165.2018.01.001
- VernacularTitle:急性缺血性卒中患者静脉溶栓后短时血压变异性与转归相关性的汇总分析
- Author:
Jingfeng MING
1
;
Xiangyu WANG
;
Shuangshuang DONG
;
Zhenjie SUN
;
Yongjin ZHANG
;
Min WANG
;
Zhengxin SONG
;
Zenglin CAI
Author Information
1. 徐州医科大学附属连云港医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Thrombolytic Therapy;
Blood Pressure;
Treatment Outcome;
Cerebral Hemorrhage;
Time Factors;
Risk Factors;
Meta-Analysis
- From:
International Journal of Cerebrovascular Diseases
2018;26(1):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between short-term blood pressure variability and poor outcome and hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke.Methods The Databases such as Wanfang,CNKI,Cochrane,Pubmed,EMBASE,and Web of Science were retrieved.The randomized controlled trials,cohort studies and case-control studies about blood pressure monitoring after intravenous thrombolytic therapy in patients with acute ischemic stroke and calculation and analysis of blood pressure variability were enrolled.The deadline for retrieval was December 2017.STATA 13.0 software was used to conduct Meta-analysis.Results A total of 9 non-randomized controlled trials with 19 161 patients were included.Four of them were prospective studies and 5 were retrospective studies.The relationship between short-term blood pressure variability and poor outcome (defined as a modified Rankin scale score ＞2) were investigated in 8 studies (a total of 19 045 patients).The relationship between short-term blood pressure variability and hemorrhagic transformation were investigated in 6 studies (with 18 456 patients).The results of Meta-analysis showed that short-term systolic blood pressure variability (every 10 mmHg change;1 mmHg =0.133 kPa) and poor outcome (odds ratio [OR] 1.55,95％ confidence interval [CI] 1.22-1.86;P ＞0.001),hemorrhagic transformation (OR 2.39,95％ CI 1.71-3.35;P =0.025),and symptomatic intracranial hemorrhage (OR 2.49,95％ CI 1.39-4.39;P =0.048) had significant correlations.Conclusion The increased short-term blood pressure variability after intravenous thrombolysis in patients with acute ischemic stroke is associated with poor outcome,hemorrhagic transformation,and symptomatic intracranial hemorrhage.
