A case of multicentric reticulohistiocytosis.
- Author:
Kyung Ho KIM
1
;
Se Woong CHOI
;
Sang Hwa LEE
;
Sung Won LEE
;
Won Tae CHUNG
;
Dae Chul KIM
;
Seong Kuk YOON
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. leesw@daunet.donga.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic disease;
Multinucleated giant cells;
Proliferating histiocytes
- MeSH:
Alendronate;
Anti-Inflammatory Agents, Non-Steroidal;
Arthritis;
Cyclosporine;
Cytoplasm;
Elbow;
Eosinophils;
Female;
Giant Cells;
Hand;
Histiocytes;
Humans;
Hydroxychloroquine;
Joints;
Methotrexate;
Middle Aged;
Mucous Membrane;
Skin;
Synovial Fluid;
Toes
- From:Korean Journal of Medicine
2004;67(Suppl 3):S850-S856
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multicentric reticulohistiocytosis (MRH) is a rare systemic disease, characterized by severe rapidly destructive polyarthritis and erythematous papulonodular skin lesions. This disorder involves primarily skin and joints, but it has been reported to affect nearly every organ system. Histological analyses of skin, mucosa and synovia reveal that multinucleated giant cells and proliferating histiocytes have smooth eosinophilic ground-glass cytoplasm. We report a case of a 46-year-old woman who was presented with multiple arthritis and erythematous patch on the V-neck and hard nodules on both hands, elbows, great toes, and auricles. About 25% of the reported patients with MRH have been associated with cancer, but MRH is not considered to be a paraneoplastic disorder. She has not been found any other malignant disease. She has been treated with NSAIDs, corticosteroid, alendronate, hydroxychloroquine, and low-dose methotrexate. Cyclosporin A was added to achieve complete remission later on. After 6 months, she was more improved in symptoms of multiple arthritis and skin nodules.
