C-reactive protein/albumin ratio predicting early death in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2017.12.005
- VernacularTitle:C反应蛋白与白蛋白比值预测急性缺血性卒中患者早期死亡
- Author:
Min BAI
1
;
Kaibin HUANG
;
Shengnan WANG
;
Zhenzhou LIN
;
Yongming WU
;
Suyue PAN
Author Information
1. 南方医科大学南方医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
C-Reactive Protein;
Serum Albumin;
Survival Rate;
Biomarkers;
Risk Factors;
Time Factors
- From:
International Journal of Cerebrovascular Diseases
2017;25(12):1083-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of C-reactive protein/albumin ratio (CAR) for 30 d survival status in patients with acute ischemic stroke.Methods Patients with acute ischemic stroke admitted to the Neurological Intensive Care Unit (NICU),Nanfang Hospital,Southern Medical University were selected from 2013 to 2016.They were divided into a survival group and a death group according to the 30 d survival status.The clinical data of both groups were compared and analyzed.Multivariate logistic regression analysis was used to determine the independent risk factors for 30 d survival status.The predictive value of the variables was analyzed using the receiver operating characteristic (ROC) curve.Results A total of 236 patients were enrolled in the study,including 64 (27.12％) in the death group and 172 (72.88％) in the survival group.The baseline National Institutes of Health Stroke Scale score,procalcitonin,C-reactive protein,CAR,and onset to NICU time in patients of the survival group were significantly lower or shorter than those of the death group,and the serum albumin level of the survival group was higher than that of the death group (all P ＜0.05).Pearson's correlation analysis showed that C-reactive protein (r =0.647,P ＜ 0.001),CAR (r =0.632,P ＜ 0.001),and onset to NICU time (r =0.596,P ＜ 0.001) were closely associated with the 30 d survival status in patients with acute ischemic stroke.Multivariate logistic regression analysis showed that CAR was an independent risk factor for 30 d mortality in patients with acute ischemic stroke (odds ratio 1.895,95％ confidence interval 1.573-2.282;P ＜ 0.001).ROC curve analysis showed that the area under the curve of CAR was 0.873 (95％ confidence interval 0.815-0.931),the optimal cut-off value was 2.197,the sensitivity of predicting 30 d death risk was 82.8％,and the specificity was 87.8％.Conclusion CAR is an independent risk factor for 30 d death in patients with acute ischemic stroke and can be used for 30 d survival assessment in patients with acute ischemic stroke.
