Correlations of P2Y1 and ITGB3 polymorphisms with aspirin resistance in patients with large artery atherosclerotic stroke
10.3760/cma.j.issn.1673-4165.2017.11.010
- VernacularTitle:P2Y1和ITGB3基因多态性与中国汉族大动脉粥样硬化性卒中患者阿司匹林抵抗的相关性
- Author:
Wenting ZHANG
1
;
Huajuan HOU
;
Hao ZHAO
;
Mingwu XIA
;
Gelin XU
;
Xinfeng LIU
Author Information
1. 230011合肥,安徽医科大学附属合肥医院,合肥市第二人民医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Atherosclerosis;
Aspirin;
Drug Resistance;
Polymorphism,Genetic;
Receptors,Purinergic P2Y1;
Integrin β3
- From:
International Journal of Cerebrovascular Diseases
2017;25(11):1018-1022
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of P2Y1 and ITGB3 single nucleotide polymorphisms (SNP) with aspirin resistance (AR) in patients with large atherosclerotic stroke (LAA) in a Chinese Han population.Methods Patients with first-ever LAA from Anhui stroke registration system were enrolled.Thrombus elasticity diagram was used to detect the platelet function.TaqMan technology was used to detect the P2Y1 and ITGB3 genotypes.Results A total of 206 patients with LAA were enrolled.Thirty-one patients (15.0％) had AR and 175 (85.0％) were aspirin sensitive (AS).The frequency of P2Y1 rs701265 G allele in the AR group was significantly higher than that in the AS group (43.5％ vs.26.9％;x2 =7.074,P=0.008).The frequency of P2Y1 rs701265 AA genotype in the AR group was significantly lower than that in the AS group (32.3％ vs.53.7％;x2 =4.850,P=0.028).There were no significant significances in the frequencies of P2Y1 rs1065776 and ITGB3 rs5918 alleles and genotypes between the AR group and the AS group.Multivariate logistic regression analysis showed that P2Y1 rs701265 G allele was an independent risk factor for AR in patients with LAA (odds ratio 2.186,95％ confidence interval 1.190-4.016;P=0.012).Conclusion The P2Y1 rs701265 polymorphism is associated with AR in Chinese Han patients with LAA,while the P2Y1 rs1065776 and ITGB3 rs5918 polymorphisms are not.
