Correlations of serum cystatin C level with severity of stroke and short-term outcome in patient with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2017.11.006
- VernacularTitle:血清胱抑素C水平与急性缺血性卒中患者卒中严重程度和短期转归的相关性
- Author:
Guodong CHEN
1
;
Jin XIAO
;
Binrong LIU
;
Jian DAI
;
Feng WANG
;
Rong ZHOU
;
Haiyan LI
;
Yongqiang JIN
;
Zhiyong WU
;
Zhaohu CHU
Author Information
1. 皖南医学院附属马鞍山市中心医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Cystatin C;
Severity of Illness Index;
Treatment Outcome;
Risk Factors;
Biomarkers
- From:
International Journal of Cerebrovascular Diseases
2017;25(11):996-1001
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of serum cystatin C level with severity of stroke and short-term outcome in patients with acute ischemic stroke.Methods Patients with first-ever acute ischemic stroke aged ≥50 years who did not receive thrombolysis and took a visit within 3 d after onset were selected prospectively.The serum cystatin C level was detected within 24 h after admission and various clinical data were collected.The National Institutes of Health Stroke Scale (NIHSS) was used to assess the neurological deficits on the day of admission.The NIHSS score ＜8 was defined as mild stroke and ≥8 was defined as moderate to severe stroke.The modified Rankin Scale (mRS) was used to evaluate the short-term outcome at discharge or 14 d after onset,0-2 was defined as good outcome and ＞2 was defined as poor outcome.Results A total of 188 patients were enrolled,including 93 (49.5％) females and 95 (50.5％) males,their mean age was 65.4 ±9.2 years old (range 50-87).There were 120 patients with mild stroke (63.8％),68 with moderate to severe stroke (36.2％);106 patients (56.4％) had good outcome and 82 (43.6％) had poor outcome.Univariate analysis showed that serum cystatin C level in the moderate to severe stroke group was significantly higher than that in the mild stroke group (1.36 ± 0.29 mg/L vs.1.21 ±0.23 mg/L;t =3.902,P ＜ 0.001),the serum cystatin C level in the poor outcome group was significantly higher than that in the good outcome group (1.38 ± 0.25 mg/L vs.1.22 ± 0.25 mg/L;t =4.101,P =0.001).Multivariate logistic regression analysis showed that the serum cystatin C level was an independent risk factor for stroke severity (odds ratio 12.182,95％ confidence interval 11.163-13.202;P ＜ 0.001) and short-term poor outcome (odds ratio 9.025,95 ％ confidence interval 8.202-9.848;P ＜ 0.001).Conclusion The serum cystatin C level is significantly correlated with the severity of stroke and the short-term outcome in patients with acute ischemic stroke.
