Clopidogrel resistance: genetic polymorphism and drug interactions
10.3760/cma.j.issn.1673-4165.2017.09.013
- VernacularTitle:氯吡格雷抵抗:基因多态性和药物相互作用
- Author:
Yang LIU
1
;
Shuangyi FAN
Author Information
1. 解放军第三○七医院神经内科
- Keywords:
Stroke;
Brain Ischemia;
Drug Resistance;
Polymorphism,Genetic;
Drug Interactions;
Platelet Aggregation Inhibitors;
Clopidogrel
- From:
International Journal of Cerebrovascular Diseases
2017;25(9):844-852
- CountryChina
- Language:Chinese
-
Abstract:
Some patients with cardiocerebral vascular diseases still have recurrent ischemic events after clopidogrel administration,suggesting clopidogrel may not play an expected antiplatelet effect.Studies demonstrated that clopidogrel resistance was seen in some patients.The mechanism of clopidogrel resistance is still unclear.This article reviews the relationship between clopidogrel resistance and gene polymorphism and drug interactions.
