Roles of aquaporin 4 in intracerebral hemorrhage
10.3760/cma.j.issn.1673-4165.2017.09.012
- VernacularTitle:水通道蛋白4在脑出血中的作用
- Author:
Xinyu WANG
1
;
Lanjun LI
;
Yuying SUN
;
Danhua DING
;
Qianqian LI
;
Jun WU
Author Information
1. 450052,郑州大学第一附属医院神经内科
- Keywords:
Cerebral Hemorrhage;
Aquaporin 4;
Blood-Brain Barrier;
Brain Edema;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2017;25(9):839-843
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporin 4 (AQP4) is the most abundant aquaporin type in the brain.It is mainly expressed in the perivascular end feet of astrocytes.A large number of studies have shown that AQP4 is involved in the formation and elimination of brain edema in intracerebral hemorrhage,and plays important roles in the maintenance of the integrity of blood-brain barrier,secondary neuroinflammation,and apoptosis after intracerebral hemorrhage.More and more studies focus on the roles and mechanisms of AQP4 in intracerebral hemorrhage,however,the results are not completely consistent.This article reviews the roles and mechanisms of AQP4 in intracerebral hemorrhage
