Analysis of drug resistance of pathogenic bacteria from different origins in neurosurgery ward
10.3969/j.issn.1673-4130.2018.13.020
- VernacularTitle:神经外科病区不同来源的致病菌耐药比较分析
- Author:
Guanghui ZHENG
1
;
Fangqiang LI
;
Yan ZHANG
;
Mingzhong TANG
;
Xixiong KANG
;
Guojun ZHANG
Author Information
1. 首都医科大学附属北京天坛医院检验科/北京市免疫试剂临床工程技术研究中心
- Keywords:
cerebrospinal fluid;
respiratory tract;
antibiotic resistance
- From:
International Journal of Laboratory Medicine
2018;39(13):1610-1614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences in antibiotic resistance among pathogenic bacteria isolated from respiratory tract and cerebrospinal fluid specimens in neurosurgery wards .Methods Antibiotic resist-ance tests were performed to analyze the antibiotic sensitivities of pathogenic bacteria isolated from respiratory tract and cerebrospinal fluid specimens in the neurosurgery wards at Beijing tiantan hospital affiliated to cap-ital medical university ,from January 2012 to December 2016 .Statistical analysis was performed using the t test or M-W test to determine the differences between the two independent samples were statistically significant . Results From January 2012 to December 2016 ,6 091 strains isolated from respiratory tract and 1 597 strains isolated from CSF specimens were obtained from patients in the neurosurgery wards of a hospital .Based on the results of the t test ,differences in the antibiotic sensitivities of pathogenic bacteria isolated from these two specimens were statistically significant .Three Gram-negative bacteria ,Pseudomonas aeruginosa ,Klebsiella pneumoniae and Acinetobacter baumannii ,showed statistically significant differences in antibiotic sensitivities between respiratory tract and cerebrospinal fluid specimens (P＜0 .05) ,but this difference was not statistically significant in Staphylococcus aureus (P＞0 .05) .Pathogenic bacteria isolated from two specimens showed sta-tistically significant differences in sensitivity to β-lactam antibiotics ,polymyxin B ,vancomycin and linezolid (P＜0 .05) .Conclusion The sensitivity differences between bacteria isolated from respiratory tract and cere-brospinal fluid specimens are statistically significant .Several reasons ,such as antibiotic-induced antibiotic re-sistance ,horizontal gene transfer are responsible for this result .
