Expression and clinical significance of autoantibodies in serum and cervical mucus in female patients with infertility
10.3969/j.issn.1673-4130.2018.13.006
- VernacularTitle:血清及宫颈黏液中自身抗体在女性不孕症患者中的表达及临床意义
- Author:
Wenfu ZHONG
1
;
Hao ZENG
;
Yuanwu YANG
Author Information
1. 广西贵港市人民医院检验科
- Keywords:
infertility;
autoantibodies;
serum;
cervical mucus;
regulatory T cells
- From:
International Journal of Laboratory Medicine
2018;39(13):1553-1556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of autoantibodies in serum and cer-vical mucus in female patients with infertility .Methods 100 cases of infertility patients (study group) ,100 ca-ses of patients (cases control group) with cervical inflammation and 100 (healthy control group) cases women without spontaneous abortion were recruited as subjects from February 2014 to February 2017 .Serum and cer-vical mucus autoantibodies and peripheral regulatory T cells (Treg) levels were detected in all subjects ,then analyzed the correlation between them .Results The study group patients′ serum and cervical mucus an-tisperm antibody ,ovarian antibody resistance ,resistance to human chorionic gonadotropin ,endometrial anti-body and thyroid autoantibodies and anti-β-2 glycoprotein 1 antibody levels were significantly higher than that of case control group and healthy control group ,the difference was statistically significant (P＜0 .05) .Treg in patients with peripheral blood levels of study group was (3 .28 ± 0 .39)%,which were significantly lower than the case control group(8 .92 ± 1 .20)% and healthy control group(9 .10 ± 1 .32)%,the difference was statisti-cally significant (P＜0 .05) .The Pearson correlation analysis available :infertility patients′serum and cervical mucus antisperm antibody ,ovarian antibody resistance ,resistance to human chorionic gonadotropin ,endome-trial antibody and thyroid autoantibodies and anti-β-2 glycoprotein 1 antibody levels were in negative correla-tion with the level of peripheral blood Treg (P＜0 .05) .Conclusion The serum of sterility patients and cervi-cal mucus of the autoantibody levels are closely related to T reg level ,and can be used as an index of clinical di-agnosis and treatment of infertility .
