The diagnosis value of TNF-α ,IL-6 and NSE in cerebrospinal fluid of children with central nervous system infection
10.3969/j.issn.1673-4130.2018.12.017
- VernacularTitle:脑脊液 TNF-α 、IL-6 、NSE在小儿中枢神经系统感染中的诊断价值
- Author:
Shulan SHI
1
;
Yanfei YANG
;
Rongjie LI
;
Junyi YANG
;
Xingxing FENG
;
Xiaojuan LI
;
Bailing ZHOU
;
Liyue KUI
;
Tingyi DU
Author Information
1. 昆明市儿童医院检验科
- Keywords:
central nervous system infection;
tumor necrosis factor-α;
interleukin-6;
neuron specific enolase;
cerebrospinal fluid;
children
- From:
International Journal of Laboratory Medicine
2018;39(12):1470-1472
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of tumor necrosis factor-alpha (TNF-α) , interleukin-6 (IL-6) and neuron enolase (NSE) in the cerebrospinal fluid of children with central nervous sys-tem infection (CNSI).Methods 54 cases of CNSI hospitalized children ,admitted in the hospital from October 2015 to January 2017 ,were enrolled in the study and divided into viral meningitis group (30 cases) and suppu-rative meningitis group (24 cases).Another 20 cases who underwent cerebrospinal fluid examination and other related examinations were enrolled in the study as the control group.The levels of three biomarkers TNF-α , IL-6 and NSE in cerebrospinal fluid of three groups were detected by enzyme linked immunosorbent assay (ELISA).Results The levels of TNF-α ,IL-6 and NSE in purulent meningitis group were the hightest ,and the levels of these three factors in viral meningitis group were highter than the control group ,and the differ-ence was statistically significant in three groups (P＜0.05).But there were a lot of data overlaps.There was no significant difference in the levels of TNF-α ,IL-6 and NSE between the brain group and the control group (P＞0.05).Conclusion The detection of TNF-α ,IL-6 and NSE in cerebrospinal fluid has a certain clinical val-ue for the diagnosis of CNSI ,but it needs to be further verified by a large sample clinical trial.
