The relationship between the level of serum 25-hydroxyvitamin D and glucose control in the patients with type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2018.12.007
- VernacularTitle:血清25羟维生素D水平与血糖控制效果在2型糖尿病中的关系研究
- Author:
Min WANG
1
;
Shuxian MIAO
;
Yanfei LU
;
Li WEI
Author Information
1. 南京医科大学第一附属医院检验学部
- Keywords:
25-hudroxyvitamin D;
type 2 diabetes mellitus;
glycosylated hemoglobin
- From:
International Journal of Laboratory Medicine
2018;39(12):1432-1435
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of serum 25-hydroxyvitamin D [25(OH)D] level and blood glucose control in patients with type 2 diabetes mellitus (T2DM).Methods The clinical data of 300 pa-tients with T2DM in the hospital were analyzed retrospectively.According to the level of glycated hemoglobin (HbA1c) ,the patients were divided into the good control of blood glucose group (＜6.5%) ,the medium con-trol of blood glucose group (6.5% -7.5%) and the poor control of blood glucose group (＞7.5%).Another 44 healthy individuals with normal glucose tolerance (NGT) confirmed by oral glucose tolerance test (OGT T) were selected as normal control group.The level of 25(OH)D in each group was compared ,and the correlation between HbA1c and 25(OH)D was analyzed.Results The level of serum 25(OH)D in the poor control of blood glucose group was significantly lower than that in the good control of blood glucose group and the con-trol group ,and the difference was statistically significant (P＜0.05) ;the levels of serum 25(OH)D in the the medium and good control of blood glucose groups were significantly lower than that in the control group (P＜0.05).HbA1c was negatively correlated with 25 (OH) D level (r= -0.212 ,P=0.000).Conclusion The level of serum 25 (OH) D is related to the development of T2DM.Proper vitamin D supplementation can be used as an adjuvant therapy for T 2DM.
