Changes of sex hormones in male patients with hyperthyroidism and hyperplasia of mammary glands
10.3969/j.issn.1673-4130.2018.12.006
- VernacularTitle:甲状腺功能亢进合并乳腺增生男性患者的性激素变化情况
- Author:
Yanqing HONG
1
Author Information
1. 黄山市人民医院内分泌科
- Keywords:
hyperthyroidism;
hyperplasia of mammary glands;
thyroid hormone;
sex hormone
- From:
International Journal of Laboratory Medicine
2018;39(12):1429-1431,1435
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of methimazole on male patients with hyperthyroidism and hyperplasia of mammary glands and its effect on sex hormone levels.Methods A total of 97 cases of hyper-thyroidism treated in the hospital from February 2014 to February 2017 were selected as the research subjects. These patients were divided into group A (patients with hyperthyroidism with mammary gland development , 33 cases) and group B (patients with hyperthyroidism ,64 cases) according to whether patients had the combi-nation of hyperplasia of mammary glands.Two groups of patients were treated with methimazole ,thyroid hor-mone levels and sex hormone levels before and after treatment were compared between the two groups.Results Before treatment ,there was no significant difference in the levels of free T 3 (FT3) ,free T4 (FT4) ,three io-dine thyroxine (T3) ,thyroxine (T4) ,and thyroid stimulating hormone (TSH) in the two groups (P＞0.05). After treatment ,the levels of FT3 ,FT4 ,T3 and T4 in both groups were significantly lower than those before treatment ,while the level of TSH was significantly higher than that before the treatment (P＜0.05).There was no significant difference in the levels of FT 3 ,FT4 ,T3 ,T4 and TSH between the two groups (P＞0.05). Before treatment ,the levels of total testosterone (T) ,luteinizing hormone (LH) ,prolactin (PRL) and estradi-ol (E2) in group A were significantly higher than those in the B group (P＜0.05).After treatment ,the levels of T ,LH ,PRL and E2 in group A were significantly lower than those before treatment (P＜0.05).After treat-ment ,the levels of T ,LH ,FSH ,PRL ,E2 ,P in the two groups were not statistically significant (P＞0.05). Conclusion Patients with hyperthyroidism combined with hyperplasia of mammary glands has a high level of sex hormones.After hyperthyroidism treatment ,thyroid hormone and sex hormone levels can be significantly changed into a better status.
