Clinical value evaluation of joint detection of lipoprotein associated phospholipase A2 and small dense low-density lipoprotein cholesterol levels in the diagnosis of patients with coronary heart disease
10.3969/j.issn.1673-4130.2018.12.004
- VernacularTitle:脂蛋白相关磷脂酶A2和小而密低密度脂蛋白胆固醇联合检测在冠心病患者诊断中的临床价值评价
- Author:
Rongrong SHI
1
;
Zhanhua WANG
Author Information
1. 兰州石化总医院检验科
- Keywords:
coronary heart disease;
lipoprotein-associated phospholipase A2;
small dense low-density lipoprotein cholesterol;
homocysteine;
combined detection
- From:
International Journal of Laboratory Medicine
2018;39(12):1421-1424,1428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of combined detection of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and small dense low-density lipoprotein cholesterol (sdLDL-C) in the clinical diagnosis of coronary heart disease.Methods 100 patients with coronary heart disease were selected as the ex-periment group ,and 50 healthy subjects who underwent the health assessment were selected as the control group.The levels of serum Lp-PLA2 ,sdLDL-C ,homocysteine (Hcy) ,triglyceride (TG) ,total cholesterol (TC) ,high density lipoprotein cholesterol (HDL-C) ,low density lipoprotein cholesterol (LDL-C) ,and the de-gree of coronary heart disease (CHD) were measured and the correlation was analyzed.Results Compared with the control group ,the level of Lp-PLA2 ,sdLDL-C and Hcy increased significantly ,and the level of HDL-C was lower ,and the difference was statistically significant (P＜0.05) ;there was a positive correlation between Lp-PLA2 and sdLDL-C ,Hcy ,TG ,TC and LDL-C (r=0.430 ,0.633 ,0.259 ,0.450 ,0.269 ,P=0.026 , 0.013 ,0.028 ,0.032 ,0.023).There was a negative correlation between Lp-PLA2 and HDL-C (r= -0.632 , P=0.01).In 0- ＜20 points ,20- ＜40 points and ≥40 points experiment groups ,the levels of Lp-PLA2 and sdLDL-C were significantly higher than those in the control group ,and the differences were significant (P＜0.05) ;there was also a significant difference in the level of Lp-PLA2 and sdLDL-C between 0- ＜20 points ,20- ＜40 points and ≥40 points experiment groups (P＜0.05).The positive rates of the combined detection of Lp-PLA2 and sdLDL-C in the acute coronary syndrome (ACS) group and the stable angina (SAP) group were significantly higher than those of the single test ,and the differences were statistically significant (χ2=4.246 , 4.974 ,P=0.039 ,0.026).Conclusion Lp-PLA2 and sdLDL-C levels are both higher in patients with coronary heart disease than those in healthy people.The combined detection of Lp-PLA2 and sdLDL-C has a certain clinical significance for assessing the development and prognosis of patients with coronary heart disease.
