Clinical value of combined detection of Hcy ,HbA1c and nephrotic index in screening for early renal injury in type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2018.11.014
- VernacularTitle:Hcy、HbA1c和肾病指数联合检测对2型糖尿病 早期肾损伤筛查的临床应用价值
- Author:
Shuyu YANG
1
;
Sugen ZENG
Author Information
1. 四川大学华西医院实验医学科
- Keywords:
type 2 diabetes mellitus;
early renal damage;
homocysteine;
glycosylated hemoglobin;
nephrotic index
- From:
International Journal of Laboratory Medicine
2018;39(11):1329-1331,1335
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of combined detection of homocysteine (Hcy) ,glycosy-lated hemoglobin (HbA1c) and nephrotic index in screening early renal injury in type 2 diabetes mellitus . Methods From January 2016 to January 2017 ,164 patients with diabetes were selected as the subjects .Ac-cording to the glomerular filtration rate ,they were divided into normal renal function group (n=49) ,renal insufficiency compensatory group (n=56) ,renal insufficiency decompensation group (n=59) ,and 60 healthy physical examination personnel were taken as the health control group .We also evaluated the diagnostic value of Hcy ,HbA1c and nephrotic index alone and combined detection in early diabetic nephropathy .Results The average level of Hcy ,HbA1c and nephropathy index in healthy control group ,normal renal function group , renal insufficiency compensation group ,and renal insufficiency decompensation group increased in turn .In the early diagnosis of renal injury in diabetic patients ,the sensitivity was HbA1c (97 .39％ ) ,the specificity was Hcy (81 .16％ ) ,the Jordan index (0 .76) ,and the rate of coincidence (92 .76％ ) were all high in the index of kidney disease .The sensitivity (99 .13％ ) and negative predictive value (98 .43％ ) of the 3 indexes were im-proved .Conclusion Combined detection of Hcy ,HbA1c and nephrotic index is of high clinical value in early detection of early diabetic nephropathy .
