Expression and significance of tumor-associated macrophages in bone marrow of chronic lymphocytic leukemia
10.3969/j.issn.1673-4130.2018.11.013
- VernacularTitle:肿瘤相关巨噬细胞在慢性淋巴细胞白血病患者骨髓中的水平及意义
- Author:
Qiong SU
1
;
Hongmei OUYANG
;
Jianxin SONG
Author Information
1. 云南省楚雄市人民医院检验科
- Keywords:
chronic lymphocytic leukemia;
macrophages;
CD68;
CD163
- From:
International Journal of Laboratory Medicine
2018;39(11):1326-1328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of macrophages in the bone marrow of chronic lympho-cytic leukemia (CLL) patients and its clinical significance in the pathogenesis of CLL .Methods Fifty-eight patients with newly diagnosed CLL were selected ,including 24 cases of Binet A ,19 cases of Binet B ,15 cases of Binet C ,and 20 patients with iron deficiency anemia were selected as control group .Immunohistochemical staining was used to detect the expression of CD68+ (M1+M2 type) and CD163 (M2 type) in CLL patients . The expression differences in bone marrow tissues of CLL patients at different stages were compared . Results The numbers of CD68+ and CD163+ cells in CLL group were significantly higher than those in con-trol group (P<0 .05) ,while those in Binet C stage patients were higher than in Binet B stage patients (P<0 .05) and those in Binet B stage patients were higher than in Binet A stage patients (P<0 .05) .The progres-sion of CLL was positively correlated with the infiltration density of CD 163+ cells (P<0 .05) .Conclusion Macrophages have a high density of infiltration in the bone marrow of CLL patients ,and the infiltration densi-ty varies in different periods of CLL .With the progresses of the disease ,macrophages infiltrated into bone marrow gradually polarize to M 2 type ,w hich is relevant with the course of CLL progress .
