Management of Eosinophilic Granuloma Occurring in the Appendicular Skeleton in Children.
- Author:
Ilkyu HAN
1
;
Eun Seok SUH
;
Sang Hoon LEE
;
Hwan Seong CHO
;
Joo Han OH
;
Han Soo KIM
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Langerhans cell histiocytosis; Indomethacin; Children
- MeSH: Adolescent; Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use; Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use; Bone Diseases/*drug therapy/radiography/radionuclide imaging; Child; Child, Preschool; Cyclooxygenase Inhibitors/*therapeutic use; Eosinophilic Granuloma/*drug therapy/radiography/radionuclide imaging; Female; Humans; Indomethacin/*therapeutic use; Infant; Male; Recurrence
- From:Clinics in Orthopedic Surgery 2009;1(2):63-67
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: We compared indomethacin therapy with the more aggressive approaches of anti-cancer chemotherapy and surgery in the treatment of isolated Langerhans cell histiocytosis (LCH) of bone in children. METHODS: Comparisons were made with respect to healing of the lesion without recurrence, time to radiological healing of the lesion, time to functional recovery, and complications related to treatment. RESULTS: Complete radiologic healing of the lesion (mean, 15.3 months) and functional recovery (mean, 5.6 months) were observed in all patients treated with either approach. No significant differences were noted in the time to complete radiologic healing or the time to functional recovery between the two groups. There were no recurrences with either approach until the last follow-up (mean, 56 months). Complications were common with anti-cancer chemotherapy, but indomethacin was well-tolerated. CONCLUSIONS: Indomethacin seems to be effective for treating isolated LCH of bone in children. Hence, morbidities associated with aggressive treatment approaches such as anti-cancer chemotherapy or surgery can be avoided.
