Study on the expression of ABCA1,PPAR,SREBP,ADPN and LXR α in patients with type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2018.10.012
- VernacularTitle:2型糖尿病患者ABCA1、PPARγ、SREBP、ADPN、LXRα表达水平及临床价值研究
- Author:
Guanqiang LI
1
;
Hui YANG
;
Xiongxin HONG
;
Yanbin WAN
;
Xiaofeng LI
;
Zhongqiu GUO
;
Qiuxia ZHANG
;
Suzhen YANG
Author Information
1. 深圳市龙岗区人民医院检验科
- Keywords:
type 2 diabetes mellitus;
ATP binding cassette transporter A1;
peroxisome proliferator ac-tivated receptor γ;
sterol regulatory element binding protein;
adiponectin;
liver X recepto α
- From:
International Journal of Laboratory Medicine
2018;39(10):1199-1201,1205
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of the expression of Adenosine Triphosphate (ATP) binding cassette transporter A1 (ABCA1),peroxisome proliferator activated receptor γ(PPARγ) and sterol regulato-ry element binding protein (SREBP),adiponectin (ADPN) and liver X recepto α(LXRα) in type 2 diabetic pa-tients.Methods 71 patients with type 2 diabetes received in the hospital from June 2015 to June 2017 were se-lected as the observation group,and 60 healthy persons who underwent the health assessment from June 2015 to June 2017 were selected as the control group.Peripheral venous blood was collected from patients with an empty stomach in the morning,serum was isolated and serum human ADPN content were measured by radio-immunoassay.The levels of serum ABCA1,PPAR γ,SREBP and LXR α were measured by Enzyme linked im-munosorbent assay.Results The serum levels of ABCA1 and ADPN in the observation group were lower than those in the control group,while serum PPARγ SREBP and LXRα levels were higher than those in the control group (P< 0.05);the diagnostic sensitivity and specificity of ABCA 1+ PPARγ+ SREBP+ ADPN + LXRα were higher than those of single detection of ABCA1,PPARγ,SREBP,ADPN and LXRα.Conclusion The levels of ABCA1 and ADPN decreased in patients with type 2 diabetes,while the levels of PPAR γ,SREBP and LXR α was increased.The five joint diagnosis of ABCA1+ PPAR γ+SREBP+ADPN+LXR α has high sensitivity and specificity.It was of important clinical value and worth further application.
