Relationship between miR-655 with the clinical features of glioma and its role in diagnosis and prognosis
10.3969/j.issn.1673-4130.2018.10.008
- VernacularTitle:miR-655和神经胶质瘤临床特征的关系及其在诊断和预后中的作用
- Author:
Haicheng YAN
1
;
Jihang XUE
;
Mengyan GAO
;
Yulian LI
;
Wei WANG
Author Information
1. 内蒙古医科大学附属医院神经外科
- Keywords:
glioma;
miR-655;
diagnose;
prognosis;
biomarker
- From:
International Journal of Laboratory Medicine
2018;39(10):1184-1187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between miR-655 with the clinical features of glioma and its role in diagnosis and prognosis.Methods The tissues and para cancerous tissues of 97 patients with glioma were collected from January 2013 to May 2017 at the Affiliated Hospital of Inner Mongolia Medical Universi-ty.The expression of miR 655 was detected by real-time fluorescence quantitative PCR,and the diagnosis and prognosis of miR-655 in glioma were analyzed.Results The expression of miR-655 in the cancerous tissues was significantly lower than that of the paracancerous tissues of the glioma (P<0.001),which was signifi-cantly related to the size of the tumor (P=0.024) and the WHO grading (P=0.002).COX regression analy-sis showed that the expression of miR-655 (P=0.004)and the degree of tumor resection(P=0.008) were in-dependent risk factors for glioma;ROC analysis showed that the area under the curve of the glioma (AUC) under the miR-655 expression was 0.959 (95% CI:0.936 -0.982);when the expression of miR-655 was 0.755,the sensitivity and specificity of the diagnosis were 89.7% and 88.7% respectively.The Kaplan Meier analysis of the expression of glioma was statistically significant (P=0.004).The lower expression of miR-655 indicated the worse the prognosis of glioma patients,the COX analysis miR-655 was an independent risk factor for the survival of glioma patients.Conclusion miR-655 can be used as a marker of poor prognosis in diagnosis and prognosis.
