Clinical distribution and antibiotic resistance of Streptococcus pneumonia isolated from pediatric patients in Guangzhou
10.3969/j.issn.1673-4130.2018.09.006
- VernacularTitle:广州地区肺炎链球菌儿童分离株临床分布及药敏特征
- Author:
Lianfen HUANG
1
;
Ruili XIE
;
Lilan PENG
;
Huamin ZHONG
;
Yongqiang XIE
;
Xiaoshan GUAN
;
Xiaocong LI
;
Xiaoguang CHEN
;
Hua LI
;
Zhenwen ZHOU
Author Information
1. 广州医科大学附属广州市妇女儿童医疗中心检验科
- Keywords:
pediatric;
Streptococcus pneumonia;
drug resistance
- From:
International Journal of Laboratory Medicine
2018;39(9):1044-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the sample type and drug resistance characteristics of Streptococcus pneu-monia(Spn)isolated from pediatric patients in Guangzhou district,and their age distribution to offer instruc-tions for prevention and clinical treatment.Methods Spn isolates were cultured and identified according to the national standard procedure for clinical laboratory operation,followed by analysis of sample type and age dis-tribution of pediatric patients with positive isolates of Spn in Guangzhou Women and Children′s Medical Cen-ter from 2013 Jan 1st to 2015 Dec 31st,drug resistance status was determined by MIC test.Results Totally, 1 243 strains of Spn were isolated,which were mainly from pediatric patients under 1 year old(42.80%).Spn isolates were mainly isolated from respiratory tract(72.81%),ear secretions(15.37%),blood(5.63%),cere-brospinal fluid(3.06%)and hydrothorax(2.01%).For all Spn isolates,the resistance rate to erythromycin, tetracycline and sulfamethoxazole was especially high as 94.93%,85.76%,73.53% respectively,with relative high resistance to penicillin G(24.70%),amoxicillin(39.59%),ceftriaxone(24.05%),meropenem(22.85%) and cefotaxime(19.89%),low resistance to quinolone antibiotics(<10.00%),and no resistance to vancomycin and linezolid.Conclusion The major age group of children with Spn infection is infants under one year old in Guangzhou,clinicians should be serious about the high resistant rate of Spn to erythromycin,tetracycline and sulfamethoxazole,the significantly increased resistant rate to penicillin,amoxicillin and ceftriaxone.Clinicians should choose antibiotics rationally according to the characteristics of drug sensitivity for better treatment.
