Analysis of relationships between expression of RIP 2 and invasion in colorectal cancer

VernacularTitle:结直肠癌中RIP2的表达与侵袭性相关性研究
Author: Guomin JING ¹ ; Liran WU ; Kun FAN ; Zhigang PEI
Author Information

1. 重庆医科大学附属一院綦江医院胃肠外科
Keywords: colorectal cancer; receptor interacting protein 2; gene interference; invasion
From: International Journal of Laboratory Medicine 2018;39(7):834-836
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of RIP2 in colorectal cancer(CRC)tissues,and the inva-sion and migration was observed after RIP2 was increased in CRC cell line.Methods 48 cases of CRC paraf-fin-embedded specimens and 56 cases of tumor-adjacent tissues were collected,and expressions of RIP2 was tested by immunohistochemistry(IHC).pEGFP-RIP2 plasmid and JetPRIME were employed to increase the RIP2 in SW480 cells,and variety of invasion and migration was tested in SW480 cells.Results It was showed that expressions of RIP2 was lower in CRC tumors than in tumor-adjacent tissues(P<0.05).After RIP2 in-creased,migration ability of SW480 cells weakened.Conclusion The expression of RIP2 was decreased in CRC tissues,and it was closely related to tumor cell's invasion and metastasis.