Pediatric primary nephrotic syndrome patients comprehensive detection of plasma protein Z and coagulation factor Ⅷ activity analysis
10.3969/j.issn.1673-4130.2018.07.014
- VernacularTitle:小儿原发性肾病综合征患者血浆蛋白Z、凝血因子Ⅷ活性的检验分析
- Author:
Fujia HUANG
1
;
Hongyan HOU
Author Information
1. 百色市人民医院儿科
- Keywords:
children with primary nephrotic syndrome;
plasma protein Z;
coagulation factor Ⅷ activity
- From:
International Journal of Laboratory Medicine
2018;39(7):815-816,819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of plasma protein Z and coagulation factor Ⅷ activity in children with primary nephrotic syndrome.Methods 94 children with primary nephrotic syndrome were se-lected as the observation group,and 63 healthy children were selected as the control group.The blood samples of peripheral blood were collected from the study group,and plasma protein Z and coagulation factor Ⅷ were measured by enzyme linked immunosorbent assay.Enzyme linked immunosorbent assay was used to measure plasma protein Z and coagulation factor Ⅷ.The changes of plasma protein Z and coagulation factor Ⅷ in the two groups were compared,and the changes of plasma protein Z and coagulation factor Ⅷ in the acute and re-covery phase,and the correlation between plasma protein Z and coagulation factor Ⅷ were observed.Results The observation group of plasma protein Z level is lower than the control group,blood coagulation factor Ⅷlevels higher than the control group,and the difference was statistically significant(P<0.05);plasma protein Z level in acute stage is lower than the recovery period,and coagulation factor Ⅷ level is higher than the recov-ery period,the differences were statistically significant(P<0.05);plasma protein Z and coagulation factor Ⅷwas negatively correlated.Conclusion The plasma protein Z level in children with primary nephrotic syn-drome is significantly reduced,and the activity of coagulation factor Ⅷ is significantly increased.Detection of plasma protein Z and coagulation factor Ⅷ level can predict primary nephrotic syndrome in children.
