The clinical significance of the combined detection of IL-6 and LTB4 on early diagnosis of children with allergic purpura and its effect on prognosis
10.3969/j.issn.1673-4130.2018.05.023
- VernacularTitle:IL-6和LTB4的联合检测对早期诊断儿童过敏性紫癜的临床意义及其对预后的影响
- Author:
Shiyan CAO
1
Author Information
1. 上海长海医院儿科
- Keywords:
IL-6;
LTB4;
combined detection;
allergic purpura
- From:
International Journal of Laboratory Medicine
2018;39(5):598-601
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of interleukin-6 (IL-6) and leukotriene B4 (LTB4) in the early diagnosis of allergic purpura(HSP) in children and its effect on prognosis.Methods A total of 68 children with Henoch-Schonlein purpura enrolled in our hospital from May 2014 to May 2016 were selected.The levels of IL-6 and LTB4 in the early stage and early recovery stage of children were detected.The significance of early diagnosis and the impact on prognosis were analyzed.Results Compared with the control group,the levels of IL-6 and LTB4 in acute and early recovery stage of children with Henoch-Schonlein purpura were significantly higher(P＜0.05),and those in the acute stage of children were higher than those in the early recovery stage(P＜0.05).The higher the level of IL-6 and LTB4 in the serum,the greater the possibility of renal damage in patients,and the difference was statistically significant (P＜0.05).The higher the level of serum IL-6 and LTB4,the higher the cure rate(P＜0.05) and the lower the recurrence rate(P＜0.05).The AUC of the combined detection of HSP was 0.894 and the sensitivity was 0.811,which were better than those of IL-6 and LTB4(P＜0.05).Conclusion Combined detection of IL-6 and LTB4 is of great clinical significance in the early diagnosis and prognosis of HSP.
