Study on the relationship between the level of D-dimer and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease
10.3969/j.issn.1673-4130.2018.05.022
- VernacularTitle:D-二聚体水平与慢性阻塞性肺疾病急性加重期预后的关系研究
- Author:
Xiang LI
1
;
Yanqing LUO
;
Lei QU
Author Information
1. 北京市石景山医院急诊科
- Keywords:
D-dimer;
AECOPD;
prognosis
- From:
International Journal of Laboratory Medicine
2018;39(5):595-597,601
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of D-dimer (D-D) level in patients with acute exacerbation of chronic obstructive disease (AECOPD) in predicting the prognosis of patients.Methods 99 patients with AECOPD in our hospital from July 2008 to December 2010 were selected as the subjects,and were divided into observation group (n=50) and control group (n=49) according to the expression of D-D in patients with positive (D-D level cutoff value of 500 g/L).The basic information and survival of the two groups of patients were investigated,and the level of serum D-D was detected by scatter turbidimetry.The receiver operating characteristic curve (ROC) was used to evaluate the predictive value of D-D on the survival of the patients.The survival time of the two groups was compared by Kaplan-Meier.Results There was no statistically significant difference in gender,age and GOLD score between the two groups (P＞0.05).The level of D-D,the time of first hospitalization,the number of re hospitalization,the first hospital mortality and re hospitalization mortality in the observation group were significantly higher than those in the control group (P＜0.05).The ROC curve showed that the truncated value of D-D was 1 171.34 g/L and 893 g/L,respectively.The average survival time of patients in the observation group was 30.37 months and the control group was 46.37 months,respectively;Kaplan-Meier study showed that the survival time of patients in the observation group was significantly lower than that in the control group (x2 =6.371,P＜0.05).Conclusion The level of D-D in patients with AECOPD is of great value in predicting the prognosis of patients,which can be used as an independent indicator of disease progression.
