Effects of glucocorticoid combined with spleen aminopeptide on immune function and pulmonary function in children with CARAS
10.3969/j.issn.1673-4130.2018.05.017
- VernacularTitle:糖皮质激素联合应用脾氨肽对CARAS患儿免疫及肺功能的影响研究
- Author:
Xianwei HAO
1
;
Yanxun TIAN
;
Yunru WANG
;
Li ZHANG
;
Limin LIU
;
Xinyue LIU
Author Information
1. 河北省邢台市第三医院儿科
- Keywords:
CARAS;
spleen aminopeptide;
glucocorticoid;
immune function;
lung function
- From:
International Journal of Laboratory Medicine
2018;39(5):577-580,584
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of glucocorticoid combined with spleen aminopeptide on immune function and pulmonary function in children with combined allergic rhinitis and asthma syndrome (CARAS).Methods A total of 166 cases of CARAS were divided into observation group (84 cases) and control group (82 cases),the patients in the control group were treated by nasal inhalation of Budesonide Aerosol,in addition to the treatment of control group the observation group was given spleen aminopeptide oral lyophilized powder for treatment,and two groups were treated continuously for 3 months.The effect of 2 groups of children,and the changes of immune and lung function before and after treatment were compared.Results Rhinitis and asthma were significantly reduced in two groups of children after treatment,and the reductions of the score of rhinitis symptoms and the asthma score in the observation group were more significant than those in the control group(P＜0.05).The humoral immunity index (IgG,IgM and IgA) of the 2 groups increased significantly after treatment.CD3+,CD4+ and the ratio of CD4+/CD8+ in the cellular immune indexes increased significantly,and CD8+ decreased significantly.The immune indexes in the observation group were significantly improved compared with those in the control group (P＜0.05).After treatment,the forced expiratory volume in one second(FEV1) and maximal expiratory flow rate (PEFR) of the 2 groups increased significantly compared with those before treatment,and the degree of increase in the observation group was significantly higher than that in the control group(P＜0.01).Conclusion Glucocorticoid combined with spleen aminopeptide could not only improve the symptoms and signs of children with CARAS,but also significantly enhance cellular immunity,humoral immunity and pulmonary function.
