Study of the expressions of NF-κB and MTA2 in infiltrating ductal carcinoma of breast and their correlation
10.3969/j.issn.1673-4130.2018.05.014
- VernacularTitle:NF-κB与MTA2在乳腺浸润性导管癌中的表达及相关性研究
- Author:
Limei HE
1
;
Jing YU
;
Yanan LI
;
Jinping XU
;
Xiaojie WANG
;
Bo GONG
Author Information
1. 上海市长宁区妇幼保健院检验科
- Keywords:
infiltrating ductal carcinoma of breast;
nuclear factor-κB;
real-time quantitative PCR
- From:
International Journal of Laboratory Medicine
2018;39(5):566-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of NF-κB and MTA2 in infiltrating ductal carcinoma of breast and their correlations to clinicopathologic character.Methods The expressions of and MTA2 in breast cancer and paired adjacent normal breast tissues of 68 breast invasive ductal cancer patients were detected by real-time quantitative PCR method,and their correlations to the clinicopathologic characteristics of breast invasive ductal cancer were analyzed.Results The expressions of NF-κB and MTA2 in breast invasive ductal carcinoma were not related to age,tumor size and histological stage (P＞0.05),and were positively correlated with lymph node metastasis and TNM stage (P＜0.05).In addition,MTA2 was highly expressed in the tissues of ER positive breast invasive ductal cancer patients (P＜0.05).There was a positive correlation between the expression of NF-κB and the expression of MTA2 in breast cancer tissue of the infiltrating ductal carcinoma of breast patients(r=0.808,P=0.012).Conclusion Measurement of NF-κB and MTA2 from breast invasive ductal carcinoma tissue may provide a theoretical basis for the diagnosis,progression and prognosis of infiltrating ductal carcinoma of breast.
