Clinical value of serum phospholipase A2 in the screening and diagnosis of benign prostatic hyperplasia
10.3969/j.issn.1673-4130.2018.04.018
- VernacularTitle:血清脂蛋白磷脂酶A 2对筛查诊断前列腺增生的临床意义
- Author:
Huawen YANG
1
;
Zhihong DIAO
;
Ting WANG
;
Houkuang QIU
;
Yanqi WEI
;
Zhi ZHANG
;
Wenfeng HUA
Author Information
1. 广东省第二人民医院检验医学部
- Keywords:
benign prostatic hyperplasia;
lipoprotein associated phospholipase A 2;
total prostate spe-cific antigen;
free prostate specific antigen;
F/T ratio
- From:
International Journal of Laboratory Medicine
2018;39(4):447-449
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of serum lipoprotein associated phospholipase A 2 (Lp-PLA2)as a biomarker for benign prostatic hyperplasia(BPH).Methods A total of 65 serum samples of BPH patients were selected as BPH group,64 serum samples of healthy male as control group.The serum lev-el of Lp-PLA2,total prostate specific antigen(tPSA)and free prostate specific antigen(fPSA)in both groups were detected,and the specificity and sensitivity of Lp-PLA2,F/T ratio and combine both were analyzed by ROC curve.Results The serum level of Lp-PLA2,tPSA and fPSA in BPH group were significantly higher than those in control group,the different were significant(P<0.05).ROC curve analyze shown that the area under the curve(AUC)of Lp-PLA2 was 0.763,95% confidence interval(CI)was 0.680-0.833;AUC of F/T ratio was 0.715,95% CI 0.633 -0.795;AUC of Lp-PLA2 combined with F/T ratio was 0.832,95% CI 0.756-0.892.Conclusion The serum level of Lp-PLA2 could be used as a potential diagnostic marker for BPH,and the diagnostic value of Lp-PLA2 combined with F/T ratio was better than ther single indicator. Key words:benign prostatic hyperplasia; lipoprotein associated phospholipase A 2; total prostate spe-cific antigen; free prostate specific antigen; F/T ratio
