Diagnosis value of lipoprotein(a)in cerebral infarction
10.3969/j.issn.1673-4130.2018.04.013
- VernacularTitle:血清脂蛋白a水平对脑血栓形成的诊断价值
- Author:
Jie HUANG
1
;
Pu ZHANG
;
Shaoxiong ZHOU
;
Yongjian SHEN
;
Weixian XIE
;
Lin ZOU
Author Information
1. 南方医科大学附属佛山医院检验科
- Keywords:
lipoprotein(a);
cerebral thrombosis;
Logistic regression;
receiver operating characteris-tic curve
- From:
International Journal of Laboratory Medicine
2018;39(4):429-431,434
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of serum lipoprotein(a)[Lp(a)]in cerebral infarction by a model of Logistic regression and receiver operating characteristic(ROC)curve.Methods A total of 316 patients with cerebral thrombosis from Foshan Hospital Affiliated to Southern Medical University were col-lected.According to the diagnostic criteria,the patients were divided into cerebral thrombosis group(196 ca-ses)and non-cerebral thrombosis group(120 cases).All the subjects were tested for Lp(a)by immune turbi-dimetry.To evaluate the diagnostic value of Lp(a)by applying logistic regression model,drawing ROC curves and calculating the area under the curve(AUC).Results The P25,P50,P75of Lp(a)in cerebral thrombosis group and non-cerebral thrombosis group were 97.23,238.22,430.01 and 29.80,92.27,233.86,the average rank were 185.42 and 114.52,the differences in the two groups were significant(P<0.05).Logistic regres-sion showed that the correlation between Lp(a)level and cerebral thrombosis was positive,the partial regres-sion coefficient(B)was 0.005,Wald value was 31.295.It suggested that when the levels of Lp(a)was higher the risk of cerebral thrombosis increased.The most valuable diagnosis level was 305.80 mg/L.And the area under the ROC curve(AUC)was 0.724,which has moderate diagnostic efficacy.Diagnostic specificity was 91.7%,misdiagnosis rate was 8.3%,negative predictive value was 48.7%,sensitivity was 40.8%,omission rate was 59.2%,positive predictive value was 88.9%.Conclusion The level of serum Lp(a)has high diag-nostic specificity for the diagnosis of cerebral thrombosis.
