Diagnostic value of combined detection of NGAL,L-FABP and KIM-1 in urine for early acute kidney injury in children
10.3969/j.issn.1673-4130.2018.03.009
- VernacularTitle:尿液中NGAL、L-FABP、KIM-1联合检测对儿童早期急性肾损伤的诊断价值
- Author:
Zhaohua WANG
1
;
Zijie DONG
;
Yanjie HAN
;
Jing ZHANG
;
Jie QI
Author Information
1. 石家庄市第四医院检验科
- Keywords:
Neutrophil gelatinase associated lipocalin;
liver type fatty acid binding protein;
kidney in-jury;
acute renal injury;
diagnosis
- From:
International Journal of Laboratory Medicine
2018;39(3):286-288,292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of combined detection of NGAL,L-FABP and KIM-1 in urine for early acute kidney injury in children.Methods 128 cases sepsis patients in our hospital during ICU from September 2015 to September 2016 were enrolled in the study,according to the occurrence of acute renal injury(AIK)were divided into observation group and control group,the incidence of AKI in 26 ca-ses as the observation group,102 cases without AKI as control group;the content of urine collected from two groups of children,NGAL L-FABP,KIM-1.Results In AKI group 6 h NGAL,L-FABP,Kim-1 in urine in-creased significantly higher than that of the other time points and non AKI group level,significant difference was statistically significant;6h NGAL,L-FABP,Kim-1 in urine combined detection efficiency is highest,sen-sitivity,specificity and positive pre detection value and negative predictive value were measured 86.7%,97. 8%,78.3% a,98.7% a,was significantly higher than the diagnostic efficacy of urinary NGAL,L-FABP,Kim-1;6h,L-FABP,NGAL in the urine level of KIM-1 and 48h in patients with creatinine and GFR levels of correla-tion analysis found that in children with early urinary NGAL,L-FABP,KIM-1 and 48h in children with creati-nine and GFR levels were positive related.Conclusion The detection of NGAL,L-FABP and KIM-1 in urine is of great significance in the diagnosis of AKI in children,which is worthy of clinical application.
