Analysis of HPV infection types distribution in normal cells and ASC-US in uterine cervix
10.3969/j.issn.1673-4130.2018.03.004
- VernacularTitle:宫颈正常细胞和不典型鳞状细胞中人乳头瘤病毒感染型别分布的分析
- Author:
Hui CAI
1
;
Jing SHEN
;
Gang YU
;
Xianhai ZHU
;
Jianxiang GENG
;
Jing MEI
;
Xiurong LONG
;
Zhaoxia YU
;
Xue ZHAO
Author Information
1. 江苏盛泽医院检验科
- Keywords:
human papillomavirus;
genotype;
gene-chip technology;
atypical squamous cells;
cer-vix
- From:
International Journal of Laboratory Medicine
2018;39(3):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical distribution and significant of 23 kinds of human papillomavir-us(HPV)genetypes in normal cells and atypical squamous cells(ASC-US),meanwhile analysis result of cervi-cal histological pathology diagnosis in cases of ASC-US.Methods A total of 1 000 women with normal cells specimens were recruited into control group,and 236 women with ASC-US were selected into the ASC-US group.Polymerase chain reaction(PCR)and gene-chips technology were utilized for the detection of 23 kinds of HPV genetypes,all cases of ASC-US diagnosis of cervical pathological histology.Results A total of 106 ca-ses of HPV infection were detected in the control group,as the total HPV infection rate was 10.6%,in which the single genotypes infection rate was 9.3% and the multiple genotypes infection rate was 1.3%.A total of 139 cases of HPV infection were detected in ASC-US group,as the total HPV infection rate was 58.9%,in which the single genotypes infection rate was 38.1%,and the multiple genotypes infection rate was 20.8%. There were significant differences on the total HPV infection rate,the infection rates of type 1 and multiple geontypes between the control group and ASC-US group(P<0.05).The top six of constituent ratio in the control group were type 43,16,58,33,52,18,42,those in the ASC-US group were type 16,18,52,58,33,51,66.Conclusion PCR combined with the gene-chip technology could be used in the HPV genotypes detection in cervical cells,which has important clinical significance on the further distribution management of ASC-US,and should be draw great attention.
