The preliminary study of Tian Jiu therapy regulating Th 1/Th2 ratio in bronchial asthma patients
10.3969/j.issn.1673-4130.2018.03.003
- VernacularTitle:三伏天灸调节支气管哮喘患者Th1/Th2比值的初步研究
- Author:
Bingjie LIAO
1
;
Yang WANG
;
Yuemei LI
;
Yingchun ZHOU
;
Shuhui LIANG
;
Jiduo LIU
;
Zhiyu PANG
Author Information
1. 广州中医药大学第一附属医院检验科
- Keywords:
asthma;
Tian Jiu;
Th1;
Th2
- From:
International Journal of Laboratory Medicine
2018;39(3):264-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether Tian Jiu therapy can regulate Th1/Th2 ratio effectively for bronchial asthma patients.Methods A total of 30 bronchial asthma patients who were treated with Tian Jiu therapy in the hospital were enrolled in the study as patients group and 20 healthy individuals were enrolled as control group.The mRNA of T-bet,GATA3,Foxp3 and STAT-6 were detected by using realtime-PCR,while IFN-γ and IL-4 were detected by using ELISA for control group and patents group before and after treatment. Flow cytometry was used to detect Th1/Th2 ratio.Results After Tian Jiu therapy,Th2 proportion decreased and Th1/Th2 ratio increased,secretion of IFN-γ decreased,mRNA of T-bet and GATA3 significantly in-creased,while STAT-6 decreased significantly(P<0.05).Conclusion Tian Jiu therapy has therapeutic effect on bronchial asthma patients through decreasing Th2 proportion and regulating Th1/Th2 ratio.
