Analysis on correlation between serum Lp-PLA2 level with ischemic stroke occurrence and prognosis in patients with hypertension
10.3969/j.issn.1673-4130.2018.02.011
- VernacularTitle:Lp-PLA2与高血压患者发生缺血性脑卒中及预后的相关性分析
- Author:
Yong QIN
1
;
Yixin ZHOU
;
Qing ZHAN
;
Ying HAN
;
Hongmei LU
;
Wei LI
;
Qin GU
;
Xuehui LING
;
Wenjie XU
Author Information
1. 上海中医药大学附属第七人民医院神经内科
- Keywords:
lipoprotein-associated phospholipase A2;
ischemic stroke;
prognosis
- From:
International Journal of Laboratory Medicine
2018;39(2):163-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level with the occurrence of ischemic stroke and prognosis in the patients with hypertension . Methods Eighty-eight patients with hypertension in this hospital from January 2013 to January 2016 were se-lected ,including 34 cases of simple hypertension and 54 cases of hypertension complicating ischemic stroke . The Lp-PLA2 level was detected .The severity of ischemic stroke was evaluated on 1 ,14 d after admission by adopting the NIHSS .The patients with hypertension complicating ischemic stroke were divided into the good prognosis group and poor prognosis group according to the NIHSS change situation .Moreover the independent predictive factors of prognosis were evaluated by adopting the Logistic multivariate regression .Results The Lp-PLA2 level in the patients with hypertension complicating ischemic stroke was significantly higher than that in the patients with simple hypertension .The Lp-PLA2 level (OR=1 .523 ,95％ CI=1 .323-1 .657) and NIHSS score (OR=3 .275 ,95％ CI=1 .402 -6 .208) at admission were the independent predictive factors of poor prognosis .Conclusion Serum Lp-PLA2 level is closely correlated with the occurrence and prognosis of ische-mic stroke in the patients with hypertension ,which can serve an evaluation index for the occurrence and prognosis of ischemic stroke in the patients with hypertension and provides an objective basis for the clinical therapy .
