Change and clinical value of thrombomodulin in children with severe pneumonia
10.3969/j.issn.1673-4130.2018.02.003
- VernacularTitle:血栓调节蛋白在儿童重症肺炎中的变化及临床价值
- Author:
Caizhi HUANG
1
;
Liya MO
;
Longgui YANG
;
Yongchao DENG
;
Cong ZHANG
;
Aiguo LI
Author Information
1. 湖南省儿童医院检验科
- Keywords:
severe pneumonia;
thrombomodulin;
endothelial cell;
children;
coagulation function
- From:
International Journal of Laboratory Medicine
2018;39(2):137-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change and clinical value of thrombomodulin (TM ) in children with se-vere pneumonia .Methods Sixty-five children cases of severe pneumonia were divided into the disseminated in-travascular coagulation (DIC) group and non-DIC group according to whether complicating DIC .And 30 healthy children were selected as the control group .Plasma TM levels were analysed and compared among the three groups .The receiver operating characteristic(ROC) curve was used to conduct the evaluation .Results The plasma TM level had statistically significant difference among the control group ,non-DIC group and DIC group(H=53 .14 ,P=0 .000) ,moreover the pairwise comparison also had statistical difference (P<0 .05) .A-mong sputum culture positive 24 cases of severe pneumonia complicating DIC ,the T M level had no statistical difference between the children patients with Gram-positive bacterial infection and children patients with Gram-negative bacterial infection(P>0 .05) .The area under ROC curve of TM for diagnosing DIC was 0 .74 . The sensitivity ,specificity ,positive likelihood ratio and negative likelihood ratio were 0 .76 ,0 .63 ,2 .05 and 0 .38 respectively .Conclusion The change of plasma TM level is associated with the severity of children with severe pneumonia ,and T M can be used as one of the reference indicators for the early diagnosis in children with severe pneumonia complicating DIC .
