Study on correlation between adropin protein and homocysteine level in patients with coronary artery disease
10.3969/j.issn.1673-4130.2018.02.002
- VernacularTitle:冠心病患者adropin蛋白与同型半胱氨酸水平的相关性研究
- Author:
Xin JI
1
;
Xiaole YUE
;
Dandan ZHAO
;
Xiaobin ZHANG
;
Rui ZHANG
;
Yongjun LI
Author Information
1. 河北医科大学第二医院检验科
- Keywords:
coronary heart disease;
adropin protein;
homocysteine
- From:
International Journal of Laboratory Medicine
2018;39(2):133-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum adropin protein and homocysteine (Hcy) level in the patients with coronary artery disease (CAD) ,and to study their relationship with CAD se-verity .Methods One hundred and seventy cases of CAD in this hospital from August 2015 to October 2016 were selected as the research subjects .Peripheral blood was collected for measuring serum adropin protein , Hcy and other conventional biochemical indicators ,and the coronary artery lesion was detected by coronary an-giography ,the severity of coronary artery lesion was assessed by SYNTAX score .Results In 170 cases of CAD ,mean serum Hcy level was (15 .92 ± 8 .31)μmol/L ,the adropin protein level in the hyperhomocysteine-mia group was lower than that in the non-hyperhomocysteinemia group ,the difference was statistically signifi-cant(P<0 .05) .Mean SYNTAX score in all cases was (21 .51 ± 11 .20) points ,and serum adropin protein was negatively correlated with Hcy level (r= -0 .169 ,P= 0 .028) ,serum Hcy level had no obvious correlation with SYNTAX score (r= 0 .124 ,P=0 .108) ,the adropin protein level was negatively correlated with SYN-TAX score (r= -0 .181 ,P=0 .018) .Generalized structural equation model showed that with the decrease of adropin protein level ,the SYNTAX score was increased (P=0 .019) ,compared with the patients without com-plicating hyperhomocysteinemia ,the SYNTAX score in the patients with hyperhomocysteinemia was much higher(P=0 .005) .Conclusion The lower the adropin protein level ,the higher the Hcy level and the severe the coronary artery lesion .
