Diagnostic value and clinical significance of serum hepcidin level in iron deficiency anemia
10.3969/j.issn.1673-4130.2018.01.015
- VernacularTitle:血清中铁调素水平对缺铁性贫血的诊断价值及临床意义
- Author:
Yunlong LI
1
;
Xiaoling DONG
;
Chenmin ZHOU
;
Chengwang JING
;
Ying ZHANG
;
Yuling GU
Author Information
1. 重庆市綦江区人民医院:血液内科
- Keywords:
hepcidin;
iron deficiency anemia;
anemia of chronic disease;
diagnosis
- From:
International Journal of Laboratory Medicine
2018;39(1):56-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and explore the differentiation value of serum hepcidin level in iron defi-ciency anemia(IDA) and anemia of chronic disease(ACD) .Methods 40 cases of IDA in the hospital from Oc-tober 2015 to February 2017 and 40 cases of ACD were selected as the ACD group and in the same period 50 healthy people undergoing physical examination served as the control group .The ELISA method was adopted to detect serum hepcidin level in each group .The levels of serum iron and total iron binding capacity (TIBC) were detected by using the ferrous benzoxazines colorimetric method .Then the serum hepcidin levels were performed the contrastive analysis and statistical processing .Results The serum hepcidin level in the IDA group was lower than that in the control group ,the difference was statistically significant (P<0 .05) ,and ser-um hepcidin level in the ACD group was higher than that in control group ,the difference was statistically sig-nificant (P<0 .05) .The areas of under the receiver operating characteristic (ROC) curve for hepcidin ,serum iron ,TIBC in the differentiation diagnosis of ACD and IDA were 0 .98 ,0 .67 and 0 .86 respectively .Conclusion Serum hepcidin level is a simple and easy method for the differentiation diagnosis of IDA and ACD ,and its accuracy is superior to that of serum iron and TIBC levels .
