Study on correlation between protein level and liver function indexes in adult Tibetan with hyperlipidemia in Ganzi County
10.3969/j.issn.1673-4130.2018.01.008
- VernacularTitle:甘孜县藏族成年高脂血症人群蛋白水平与肝功指标的相关性研究
- Author:
Sichong REN
1
;
Dewu NG ZHA
;
Yanchun NG HUA
;
Jun YANG
;
Ping PENG
Author Information
1. 四川大学华西医院龙泉医院检验科/成都市龙泉驿区第一人民医院检验科
- Keywords:
Tibetan;
hyperlipidemia;
albumin;
alanine aminotransferase
- From:
International Journal of Laboratory Medicine
2018;39(1):28-31,37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the albumin(ALB) and total protein(TP) levels among adult Tibetans with different clinical types of hyperlipidemia in Ganzi County and its correlation with serum liver function in-dexes .Methods The serum was collected from 661 volunteers in Ganzi County .The blood lipid metabolism indexes ,liver function indexes and serum protein levels were measured .The hyperlipidemia was performed the clinical typing according to the Guide on Prevention and Treatment of Chinese Adult Dyslipidemia in 2007 . The statistical analysis was conducted by using the one-way ANOVA variance ,Pearson correlation and multi-ple linear regression analytical methods .Results The hypercholesterolemia group ,hypertriglyceridemia group ,mixed hyperlipidemia group and low high-density lipoprotein hyperlipidemia group had 212 ,140 ,85 ,43 cases respectively ,while 181 cases were in the non-hyperlipidemia .The TP level in the patients with mixed hy-perlipidemia was significantly higher than that in the patients with non-hyperlipidemia ,the difference was sta-tistically significant (P<0 .05) .The liver function indexes ALT ,AST and γ-GGT levels in the hypercholes-terolemia group ,hypertriglyceridemia group and mixed hyperlipidemia group were significantly higher than those in the non-hyperlipidemia group ,the difference was statistically significant (P<0 .05) .The serum pro-tein level was strongly correlated with ALT and AST in the hypertriglyceridemia group and mixed hyperlipi-demia group ,the difference was statistically significant (P<0 .05) .TP serving as the dependent variable and ALB ,ALT and AST as independent variables ,the regression analysis showed TP=25 .149+1 .066(ALB)-0 .158(ALT)+0 .268(AST) in hypercholesterolemia ,TP= 28 .211+ 1 .011(ALB) -0 .067(ALT)+ 0 .176 (AST) in mixed hyperlipidemia and TP=37 .86+0 .79(ALB)-0 .079(ALT)+0 .162(AST) in non-hyperlipi-demia .Conclusion TC and TG can induce the damage of liver function in hyperlipidemia ,ALT and AST are the important indicators affecting serum protein level in the patients with hyperlipidemia .In Tibetan adult population of the Ganzi county ,only the TP level change is noticeably among the patients with mixed hyperlip-idemia ,which may be related with strong compensatory ability of liver function in Tibetan population .
