Advances in Shh signaling pathway of renal interstitial fibrosis
10.3760/cma.j.issn.1673-4408.2018.10.010
- VernacularTitle:Shh信号通路与肾小管间质纤维化
- Author:
Haisheng XU
1
Author Information
1. 154002,佳木斯大学附属第一医院儿科
- Keywords:
Sonic hedgehog;
Renal interstitial fibrosis;
Epithelial-mesenchymal transition;
Pericyte
- From:
International Journal of Pediatrics
2018;45(10):779-782
- CountryChina
- Language:Chinese
-
Abstract:
Sonic hedgehog signaling pathway has a unique role in the process of renal fibrosis,while it is mainly expressed in the impaired renal tubular epithelial cells. Shh signaling pathway promotes the process of epithelial-mesenchymal transition and renal tubulointerstitial fibrosis. Shh signaling pathway ligand triggers cell proliferation in the pericyte,suggesting a possible role for this pathway in the regulation of cell cycle progression of myofibroblasts progenitors during the development of renal fibrosis. Shh protein can be expressed at the early stage of kidney injury,which indicates that Shh signaling pathway is involved in the tissue repair process after kidney injury at the early stage. The process of renal interstitial fibrosis related to signaling pathway is involved with signaling pathway and proteins,cytokines,extracellular matrix,complement and so on. This paper reviews the progress in the study of the relationship between Shh and renal interstitial fibrosis.
