IgE and Non-IgE mediate the activation of human mast cells
10.3760/cma.j.issn.1673-4408.2018.09.013
- VernacularTitle:IgE与非IgE介导人肥大细胞的活化及相关疾病诊治
- Author:
Qiying YU
1
;
Wangming SUN
;
Yan SUN
;
Xiangyan ZENG
;
Xiaoli BAI
Author Information
1. 325027,温州医科大学附属第二医院育英儿童医院哮喘及变态反应免疫治疗中心
- Keywords:
IgE;
Mast cell;
Allergic disease
- From:
International Journal of Pediatrics
2018;45(9):701-704
- CountryChina
- Language:Chinese
-
Abstract:
Mast cells are crucial effector cells in allergic reactions,where IgE is the most notably mechanism to trigger their degranulation and release large amounts of allergic mediators.However,IgE is not the only way to stimulate these cells to degranulate.There is a lot of stimuli,such as complement,neuropeptides,cytokines and other inflammatory products,which can directly trigger mast cell degranulation,and cause selective release of mediators.These mediators are closely related to many allergic and inflammatory diseases.The paper will focus on the activation of non-IgE stimulated human mast cells,and describe the allergic and inflammatory diseases briefly,and provide the theoretical basis for clinical detection,diagnosis and treatment.
