Maternal status of vitamin D and risk of childhood wheeze: a systematic review and meta-analysis

VernacularTitle:孕期维生素D水平与儿童喘息相关性的系统评价及Meta分析
Author: Rongxuan HU ¹ ; Xiaohong GU ; Yueling XI
Author Information

1. 214000,无锡市儿童医院呼吸科
Keywords: Vitamin D; Wheeze; Pregnancy
From: International Journal of Pediatrics 2018;45(8):645-648
CountryChina
Language:Chinese
Abstract: Objective To assess the association between vitamin D levels during pregnancy and the risk of offspring's wheeze.Methods We searched electronic databases of PubMed and EMbasefrom published studies until July 2017.A random-effects meta-analysis was conducted among 11 birth cohort studies.Results Eleven studies on the association between maternal vitamin D status and childhood wheeze met our inclusion criteria.Maternal vitamin D status during pregnancy was associated with childhood wheeze(OR =0.97,95％ CI:0.96 ～ 0.99).Maternal intake of vitamin D(pooled OR =0.51,95 ％ CI:0.37 ～ 0.64),cord blood 25 (OH)D levels at birth (pooled OR =0.94,95％ CI:0.9 ～ 0.98) were associated with childhood wheeze.Furthermore,maternal vitamin D stasus were only associated with childhood early wheeze(OR =0.92,95％ CI:0.89 ～0.96),but not with late-onset or persistent wheeze.Conclusion High levels of vitamin D during pregnancy are inversely associated with the risk of wheeze during childhood.