Advances in the evaluation of anthracycline-induced cardiotoxicity in children with malignant tumors
10.3760/cma.j.issn.1673-4408.2018.08.016
- VernacularTitle:蒽环类药物治疗儿童恶性肿瘤所致心脏毒性的评价研究进展
- Author:
Yanhua NIU
1
Author Information
1. 200062,上海交通大学附属上海市儿童医院心血管内科
- Keywords:
Anthracyclines;
Malignant tumors in children;
Cardiotoxicity;
Evaluation
- From:
International Journal of Pediatrics
2018;45(8):640-644
- CountryChina
- Language:Chinese
-
Abstract:
Anthracyclines are a class of chemotherapeutic drugs derived from Streptomyces faecalis,which are non-specific cytotoxic drugs in the cell cycle.They are widely used as fast-line chemotherapeutic drugs for the treatment of childhood leukemia,lymphoma,solid tumors and have a broad anti-tumor effect.However,side effects caused by anthracyclines included cardiotoxicity,myelosuppression,alopecia,etc,especially cardiotoxicity is often progressive and irreversible,strongly affecting the long-term quality of life of children.The early detection,diagnosis and corresponding intervention of anthracycline-induced cardiotoxicity are the research hotspots of clinical heart damage.There are many methods for monitoring the anthracycline-induced cardiotoxicity.How to effectively monitor the anthracycline-induced cardiotoxicity is particularly important.This article reviews the progress about the evaluation of anthracycline-induced cardiotoxicity.
